• Inoperable tumors close to critical structure
  • Uses high voltage, low energy electrical pulses to achieve tissue necrosis
  • No heat sink effect
  • Does not rely on heat to ablate tissue


NanoKnife - What is it?

An ablation procedure that uses low energy electrical pulses to create defects (pores) in cell membranes, resulting in loss of homeostasis and subsequent cell death.

  • Uses high voltage, but low energy direct current (LEDC) – and does not rely on heat to create the tissue effect. This allows physicians to treat soft tissue near critical structures, like blood vessels, ducts, or lymph nodes.
  • Well suited for patients who have non- resectable soft tissue disease near critical structures and who otherwise have no other treatment option given the location of their disease.

How NanoKnife® Technology Works ?

  • Rapid series of short, electrical pulses
  • Low energy direct current (LEDC).
  • Ablation effect is not thermal
  • Nano‐sized defects (“pores”) created in cell membrane
  • Cell death occurs (mimics natural cell death).
  • Resulting debris eliminated through vascular pathways

NanoKnife® : Clinical Advantages

  • Provides potential to spare critical structures – vasculature and ducts remain intact
  • Ablated tissue removed by the body’s natural processes within weeks (mimics natural cell death)
  • Provides predictable zone of ablation (treatment area)
  • Patients report experiencing minimal to no post procedural pain

NanoKnife: Where is it used?

Inoperable tumors of:

  • Liver
  • Lung
  • Kidney
  • Pancreas
  • Prostrate
  • For ablating tumors close to critical structures or tumors close to blood vessels.